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Dorsal blastopore lip of embryo3/10/2024 ![]() Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. Tailbud determination in the vertebrate embryo. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Wang, S., Krinks, M., Lin, K., Luyten, F. Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Axis formation and patterning in zebrafish. The development of the posterior body in zebrafish. Origin and organization of the zebrafish fate map. Bmp activity gradient regulates convergence extension during zebrafish gastrulation. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage. Axis-inducing activities and cell fates of the zebrafish organizer. Saùde, L., Wooley, K., Martin, P., Driever, W. Transplantation experiments on developing teleosts (Fundulus and Perca). Über Induktion von Embryoalanlagen durch Implantation artfremder Organisatoren. In contrast to induction of the vertebrate head, known to result from the triple inhibition of BMP, Nodal and Wnt 5, here we show that induction of the tail results from the triple stimulation of BMP, Nodal and Wnt8 signalling pathways. Moreover, stimulation of naive cells by a combination of BMP, Nodal and Wnt8 mimics the tail-organizing activity of the ventral margin and induces surrounding tissues to become tail. Loss-of-function experiments reveal that bone morphogenetic protein (BMP), Nodal and Wnt8 signalling pathways are required for tail development. Here we reveal, by isochronic and heterochronic transplantation, the existence of a tail organizer deriving from the ventral margin of the zebrafish embryo, which is independent of the dorsal Spemann organizer. However, whereas the graft can induce ectopic head and trunk, endogenous and ectopic axes fuse in the posterior part of the body 3, 4, raising the question of whether a distinct organizer region is necessary for tail development. The equivalent of this organizer region has been identified in different vertebrates including teleosts 2. Based on grafting experiments, Mangold and Spemann showed the dorsal blastopore lip of an amphibian gastrula to be able to induce a secondary body axis 1.
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